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MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino acid peptide encoded by mitochondrial DNA. It plays a critical role in regulating metabolism, insulin sensitivity, and energy balance. First discovered in 2015, MOTS-c has gained attention for its potential in metabolic health, exercise performance, and longevity research.
Research suggests that MOTS-c interacts with key metabolic pathways such as AMPK activation, enhancing energy production and mitochondrial function. Its ability to regulate glucose metabolism and reduce fat accumulation makes it a promising target for research into metabolic disorders and aging.
Scientific research has explored several key applications of MOTS-c, including:
MOTS-c has been shown to improve glucose uptake in skeletal muscle and regulate insulin sensitivity. In laboratory studies, MOTS-c treatment reduced obesity and enhanced metabolic flexibility by promoting fat utilization. Research suggests it may also influence mitochondrial activity, leading to improved energy production and metabolic balance.
Studies indicate that MOTS-c enhances insulin action, particularly in skeletal muscle, where it increases glucose uptake. In aged mouse models, MOTS-c supplementation restored insulin sensitivity to levels comparable to younger mice. Researchers are investigating its potential role in managing insulin resistance and type 2 diabetes.
Endogenous MOTS-c levels have been observed to rise in response to exercise, linking this peptide to improved endurance and enhanced muscle energy utilization. Studies suggest that MOTS-c enhances oxidative metabolism, making it a key area of interest in sports science and performance research.
Recent research highlights the potential role of MOTS-c in bone metabolism. Studies suggest that MOTS-c promotes osteoblast (bone-forming cell) activity while inhibiting osteoclast (bone-resorbing cell) activity. This dual action may contribute to bone density maintenance and protection against osteoporosis.
MOTS-c levels decline with age, prompting researchers to investigate its potential role in longevity. Studies have found that MOTS-c supplementation improves mitochondrial function, reduces inflammation, and enhances metabolic efficiency. These factors are closely associated with increased lifespan and healthspan.
For researchers exploring mitochondrial biology, metabolic health, and longevity, MOTS-c presents a promising avenue of study. Visit DN Research today to secure your supply of this innovative peptide.
This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.
Keep this product out of the reach of children. Limited research is available on its effects, and improper handling or consumption may lead to adverse effects. This product is intended for research use only and should only be handled by professionals with the proper knowledge and equipment. By purchasing this product, you agree to indemnify DN Research against any adverse effects resulting from misuse.
The information provided is for educational and research purposes only. This product is not a pharmaceutical or medication, and it has not been approved by the FDA for the treatment, prevention, or diagnosis of any disease or medical condition.